SCHEMBL11536877

SCHEMBL11536877

Brc1ccc2c(c1)Nc1ccccc1O2

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 9/20 0.65
AHR P35869 3/20 0.59
HTR2B P41595 2/20 0.47
HTR7 P34969 1/20 0.47
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
GAA P10253 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
LMNA P02545 1/20 0.40
ALPL P05186 1/20 0.40
HSP90AA1 P07900 1/20 0.40
ALPI P09923 1/20 0.40
MAPT P10636 1/20 0.40
ALPG P10696 1/20 0.40
TLR9 Q9NR96 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31168827 1.00 ALOX5 (0.65) ALOX5AHRHTR2BHTR7MEN1
SCHEMBL13833013 0.89 ALOX5 (0.65) ALOX5AHRHTR2BHTR7MEN1
SCHEMBL30839233 0.89 ALOX5 (0.65) ALOX5AHRHTR2BHTR7MEN1
SCHEMBL46736 0.86 AHR (0.56) ALOX5AHRHTR2BHTR7MEN1
SCHEMBL28916089 0.86 ALOX5 (0.57) ALOX5AHRHTR2BHTR7MEN1
Phenoxazine SCHEMBL29355714 0.81 ALOX5 (1.00) ALOX5HTR2BHTR7MEN1KMT2A
Phenoxazine SCHEMBL28844098 0.81 ALOX5 (1.00) ALOX5HTR2BHTR7MEN1KMT2A
Phenoxazine SCHEMBL6310178 0.81 ALOX5 (1.00) ALOX5HTR2BHTR7MEN1KMT2A
Phenoxazine SCHEMBL7862 0.81 ALOX5 (1.00) ALOX5HTR2BHTR7MEN1KMT2A
SCHEMBL3409888 0.80 AHR (0.49) ALOX5AHRMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116874513-A Boron-containing heterocyclic compound and application thereof 北京八亿时空液晶科技股份有限公司 2023-10-13 CN disclosed
CN-116675682-A Phenoxazine compound, and preparation method and application thereof 郑州大学 2023-09-01 CN disclosed
CN-116041380-A Silicon-containing organic compounds, mixtures, compositions and organic electronic devices 广州华睿光电材料有限公司 2023-05-02 CN disclosed
CN-108863918-B Arylamine derivative and organic electroluminescent device thereof 长春海谱润斯科技股份有限公司 2022-02-11 CN disclosed
CN-111560031-A Polycyclic aromatic compound, reactive compound, polymer compound, crosslinked polymer, and use thereof 学校法人关西学院 2020-08-21 CN disclosed
CN-108832013-B Organic electroluminescent device 长春海谱润斯科技有限公司 2020-06-12 CN disclosed
US-4132794-A 10-Imidoylacridan compositions MEAD JOHNSON & COMPANY (US) 1979-01-02 US disclosed
US-4094981-A SMOOTH MUSCLE RELAXANT EMPLOYING 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1978-06-13 US disclosed
US-4046891-A Smooth muscle relaxant process employing 10-imidoylphenoxazines MEAD JOHNSON & COMPANY (US) 1977-09-06 US disclosed
US-3962252-A 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1976-06-08 US disclosed