SCHEMBL46736

SCHEMBL46736

Brc1ccc2c(c1)Nc1ccc(Br)cc1O2

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.56
ALOX5 P09917 6/20 0.45
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
BLM P54132 1/20 0.37
TGM2 P21980 1/20 0.36
CES1 P23141 1/20 0.36
CA12 O43570 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
CA1 P00915 1/20 0.36
CA4 P22748 1/20 0.36
CA7 P43166 1/20 0.36
CMA1 P23946 1/20 0.35
HTR2B P41595 2/20 0.35
HTR7 P34969 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29689592 0.92 AHR (0.58) AHRALOX5LMNAMAPTHTT
SCHEMBL1985922 0.92 AHR (0.58) AHRALOX5LMNAMAPTHTT
SCHEMBL28731967 0.88 AHR (0.47) AHRALOX5
Benzene SCHEMBL28149598 0.88 AHR (0.54) AHRALOX5LMNAMAPTHTT
SCHEMBL30839233 0.86 ALOX5 (0.65) AHRALOX5LMNAMAPTHTR2B
SCHEMBL13833013 0.86 ALOX5 (0.65) AHRALOX5LMNAMAPTHTR2B
SCHEMBL31168827 0.86 ALOX5 (0.65) AHRALOX5LMNAMAPTHTR2B
SCHEMBL11536877 0.86 ALOX5 (0.65) AHRALOX5LMNAMAPTHTR2B
SCHEMBL27344608 0.84 ACE2 (0.46) AHRALOX5
SCHEMBL13082340 0.81 AHR (0.47) AHRALOX5LMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111087360-A Diamine with novel structure and preparation method and application thereof 湖南工业大学 2020-05-01 CN disclosed
CN-111072585-A Diamine containing phenoxazine and amide structures and polyimide thereof 湖南工业大学 2020-04-28 CN disclosed
CN-111018850-A Diamine containing phenoxazine structure and polymer thereof with antibacterial effect 湖南工业大学 2020-04-17 CN disclosed
CN-107501292-A A kind of electroluminescent organic material and its organic luminescent device 长春海谱润斯科技有限公司 2017-12-22 CN disclosed
WO-2012003642-A1 FUSED TRICYCLIC COMPOUNDS AND USE THEREOF FOR TREATING VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2012-01-12 WO disclosed