Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.39 |
| ▸ | CHKA known ✓ | P35790 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178715 | 0.98 | ACHE (0.37) | ACHEBCHELMNACHKAALDH1A1 | |
| Hydrochloric Acid SCHEMBL1179928 | 0.97 | LMNA (0.38) | ACHEBCHELMNACHKAALDH1A1 | |
| Bromide SCHEMBL11536021 | 0.68 | LMNA (0.39) | ACHEBCHELMNACHKAALDH1A1 | |
| Bromide SCHEMBL11534508 | 0.66 | IDO1 (0.40) | ACHEBCHEALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL3601825 | 0.63 | ACHE (0.89) | ACHEBCHE | |
| SCHEMBL1127774 | 0.60 | ACHE (0.85) | ACHEBCHE | |
| Bromide SCHEMBL11535779 | 0.60 | LMNA (0.45) | ACHEBCHELMNACHKAALDH1A1 | |
| Bromide SCHEMBL365151 | 0.60 | CHKA (0.61) | ACHEBCHELMNACHKAALDH1A1 | |
| Bromide SCHEMBL28611338 | 0.60 | CHKA (0.61) | ACHEBCHELMNACHKAALDH1A1 | |
| Water SCHEMBL11536478 | 0.60 | KDM4E (0.39) | ACHEBCHEALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163745-A | ANTIDIABETIC, HYPOGLYCEMIC | PFIZER INC. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4141898-A | Imidazo pyridinium quaternary salts as hypoglycemic agents | PFIZER INC. (US) | 1979-02-27 | — | — | US | disclosed |
| US-4129567-A | IMIDAZOPYRIDINES AND ISOB IDINE | PFIZER INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4093616-A | PYRROLO(1,2-A)PYRAZINIUM, PYRAZOLO(1,5-A)PYRIDINIUM, 1H-IMIDAZO(2,1-A)ISOQUINOLINIUM, OR IMIDAZO(5,1-A)ISOQUINOLINIUM SALTS | PFIZER INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4044015-A | Imidazopyridinium compounds as hypoglycemic agents | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |