Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538355 | 1.00 | AKR1C3 (0.49) | AKR1C3FBP1CYP1A2CYP2C9KMT2A | |
| SCHEMBL11542735 | 0.80 | PTGES2 (0.56) | AKR1C3FBP1CYP2C9PTGES2 | |
| SCHEMBL11542733 | 0.80 | PTGES2 (0.56) | AKR1C3FBP1CYP2C9PTGES2 | |
| SCHEMBL4619195 | 0.80 | AKR1C3 (0.50) | AKR1C3FBP1PTGES2ALDH1A1 | |
| SCHEMBL5419434 | 0.80 | AKR1C3 (0.50) | AKR1C3FBP1PTGES2ALDH1A1 | |
| SCHEMBL5418658 | 0.80 | AKR1C3 (0.50) | AKR1C3FBP1PTGES2ALDH1A1 | |
| SCHEMBL14198038 | 0.77 | FBP1 (0.53) | AKR1C3FBP1CYP1A2CYP2C9KMT2A | |
| SCHEMBL11539749 | 0.77 | MEN1 (0.52) | KMT2AMEN1MAPTCHRM5KDM4E | |
| SCHEMBL11539745 | 0.77 | MEN1 (0.52) | KMT2AMEN1MAPTCHRM5KDM4E | |
| SCHEMBL11547520 | 0.75 | GLO1 (0.57) | AKR1C3FBP1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |