Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538373 | 1.00 | GAA (0.44) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL3587332 | 0.84 | POLB (0.51) | TSHRALDH1A1POLBSMN1; SMN2ATM | |
| SCHEMBL29543136 | 0.84 | POLB (0.51) | TSHRALDH1A1POLBSMN1; SMN2ATM | |
| SCHEMBL18307651 | 0.81 | GAA (0.48) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL15424547 | 0.81 | GAA (0.48) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL14243070 | 0.81 | CHRNB2 (0.51) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL317572 | 0.79 | BIRC2 (0.45) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL956554 | 0.79 | BIRC2 (0.45) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL952240 | 0.79 | BIRC2 (0.45) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL30767290 | 0.79 | CHRNB2 (0.57) | TSHRL3MBTL1SCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4138566-A | Piperazinyl cyclobutenones | G. D. SEARLE & CO. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4036828-A | 3,4-Bis(4-substituted piperazinyl)-3-cyclobutene-1,2-diones and related compounds | G. D. SEARLE & CO. (US) | 1977-07-19 | — | — | US | disclosed |