Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587332 | 1.00 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL20912047 | 0.84 | POLB (0.56) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL11538373 | 0.84 | GAA (0.44) | POLBSMN1; SMN2ALDH1A1ATMTSHR | |
| SCHEMBL11538376 | 0.84 | GAA (0.44) | POLBSMN1; SMN2ALDH1A1ATMTSHR | |
| SCHEMBL15244126 | 0.83 | SMN1; SMN2 (0.49) | POLBLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29409415 | 0.83 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL27464999 | 0.83 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL1669232 | 0.83 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL16111541 | 0.82 | LMNA (0.50) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL4968757 | 0.81 | LMNA (0.53) | POLBLMNASMN1; SMN2GBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4208261-A1 | USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS | Revolution Medicines, Inc. (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2022060583-A1 | USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS | Revolution Medicines, Inc. (US) | 2022-03-24 | — | — | WO | disclosed |