SCHEMBL11538545

SCHEMBL11538545

OCCOc1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 4/20 0.54
PTGS2 P35354 1/20 0.54
ALDH1A1 P00352 1/20 0.54
RECQL P46063 1/20 0.54
NR1I2 O75469 1/20 0.48
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
GAA P10253 1/20 0.46
AGER Q15109 1/20 0.45
DRD4 P21917 4/20 0.44
DRD2 P14416 3/20 0.44
DRD3 P35462 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
KCNH2 Q12809 1/20 0.44
CYP3A4 P08684 1/20 0.44
ALDH3A1 P30838 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-(4-Chlorphenoxy)-Ethanol SCHEMBL77500 0.94 ALDH1A1 (0.60) LTA4HPTGS2ALDH1A1RECQLNR1I2
2-(4-Chlorphenoxy)-Ethanol SCHEMBL11264357 0.91 ALDH1A1 (0.58) ALDH1A1RECQLNR1I2MAOBGAA
SCHEMBL347186 0.89 ALDH1A1 (0.65) LTA4HALDH1A1RECQLNR1I2GAA
Ethylene Glycol SCHEMBL27348084 0.87 ALDH1A1 (0.62) LTA4HALDH1A1RECQLNR1I2GAA
SCHEMBL27982425 0.87 ALDH1A1 (0.62) LTA4HALDH1A1RECQLNR1I2GAA
SCHEMBL9713832 0.86 ALDH1A1 (0.48) LTA4HPTGS2ALDH1A1RECQLNR1I2
Ethylene Glycol SCHEMBL11585117 0.84 MAOA (0.58) LTA4HPTGS2ALDH1A1MAOAMAOB
SCHEMBL11358240 0.84 LTA4H (0.57) LTA4HALDH1A1RECQLNR1I2MAOA
SCHEMBL14901528 0.83 ALDH1A1 (0.54) LTA4HALDH1A1RECQLNR1I2GAA
SCHEMBL4383977 0.83 DRD4 (0.52) ALDH1A1RECQLDRD4DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4156011-A TREATMENT OF CARDIOVASCULAR DISORDERS SOCIETE ANONYME DITE: LABORATOIRE L. LAFON (FR) 1979-05-22 US disclosed