Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 12/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537274 | 0.81 | MEN1 (0.36) | P2RX7HSD11B1LMNATSHRMAPK1 | |
| SCHEMBL14112935 | 0.73 | PI4KA (0.40) | ALDH1A1TSHR | |
| SCHEMBL11537218 | 0.73 | HCAR1 (0.40) | P2RX7HSD11B1ALDH1A1 | |
| SCHEMBL1493493 | 0.71 | ALDH1A1 (0.47) | P2RX7ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL11091625 | 0.70 | HCAR1 (0.40) | ALDH1A1TSHR | |
| SCHEMBL14204026 | 0.67 | FGFR1 (0.47) | ALDH1A1HTT | |
| SCHEMBL11538267 | 0.66 | NOTUM (0.38) | HSD11B1ALDH1A1LMNATSHRHTT | |
| SCHEMBL14951333 | 0.65 | P2RX7 (0.36) | P2RX7ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL14112937 | 0.65 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL2550381 | 0.65 | NOTUM (0.46) | ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134914-A | 1-Acyl-4-substituted phenyl thiosemicarbazides | ELI LILLY AND COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4082762-A | 4-(2-HALOPHENYL)-1,2,4-TRIAZOLE-3-THIOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-3937713-A | Process for the preparation of s-triazolo[3,4-b]benzothiazoles | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | disclosed |