Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11674874 | 0.80 | PTGES (0.48) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL22289157 | 0.70 | NPC1 (0.46) | KMT2AMEN1MAPTLMNADHODH | |
| SCHEMBL22302269 | 0.66 | KMT2A (0.56) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL11596321 | 0.65 | RXFP1 (0.72) | KMT2AMAPTALDH1A1GAADHODH | |
| SCHEMBL22302245 | 0.62 | FPR2 (0.44) | KMT2AMEN1ALDH1A1LMNAGAA | |
| SCHEMBL10388197 | 0.61 | MEN1 (0.51) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL9562844 | 0.61 | DHODH (0.55) | KMT2AMEN1ALDH1A1LMNAGAA | |
| SCHEMBL1929165 | 0.60 | NPC1 (0.85) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL20963276 | 0.60 | MEN1 (0.59) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL1703428 | 0.60 | DHODH (0.51) | KMT2AMEN1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082757-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1978-04-04 | — | — | US | claimed |
| US-4154734-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4134897-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4127585-A | Isoxazol amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
| US-4082757-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1978-04-04 | — | — | US | disclosed |