SCHEMBL11540249

SCHEMBL11540249

NNc1ccc(Sc2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.59
PTGS2 P35354 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
LMNA P02545 1/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
IDO1 P14902 1/20 0.59
CYP2C19 P33261 1/20 0.59
MAOA P21397 3/20 0.45
MAOB P27338 3/20 0.45
PTGIR P43119 1/20 0.43
SLC6A4 P31645 1/20 0.42
HPGD P15428 2/20 0.42
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.40
MAPK1 P28482 2/20 0.40
CHRNA7 P36544 1/20 0.40
CTSK P43235 1/20 0.39
HTR2C P28335 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4851422 0.90 LMNA (0.48) CYP3A4PTGS2TDP1LMNACYP1A2
SCHEMBL17948202 0.80 ALDH1A1 (0.60) CYP3A4PTGS2TDP1LMNACYP1A2
SCHEMBL11543435 0.79 MAPT (0.53) CYP3A4PTGS2TDP1LMNACYP1A2
SCHEMBL31332184 0.79 PTGIR (0.49) CYP3A4PTGS2TDP1LMNACYP1A2
SCHEMBL14683165 0.79 MEN1 (0.49) CYP3A4PTGS2TDP1LMNACYP1A2
SCHEMBL23277364 0.79 MAOA (0.62) CYP3A4MAOAMAOBSLC6A4HPGD
SCHEMBL795030 0.79 MAOA (0.62) CYP3A4MAOAMAOBSLC6A4HPGD
SCHEMBL3891569 0.79 MAOA (0.62) CYP3A4MAOAMAOBSLC6A4HPGD
SCHEMBL3891151 0.79 MAOA (0.62) CYP3A4MAOAMAOBSLC6A4HPGD
Hydrochloric Acid SCHEMBL14675465 0.77 MEN1 (0.47) CYP3A4PTGS2TDP1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4179439-A Rifamycins and method for their preparation INTREPRINDEREA DE ANTIBIOTICE IASI (RO) 1979-12-18 US disclosed