Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540730 | 0.88 | MAPT (0.48) | MAPTMAPK1ALOX15PARP1ALDH1A1 | |
| SCHEMBL11541423 | 0.87 | MAPT (0.59) | MAPTMAPK1ALOX15ALDH1A1RAB9A | |
| SCHEMBL11541127 | 0.86 | ALDH1A1 (0.47) | MAPTMAPK1PARP1ALDH1A1RAB9A | |
| SCHEMBL11540900 | 0.84 | MAPT (0.52) | MAPTMAPK1ALDH1A1RAB9ALMNA | |
| SCHEMBL11543650 | 0.82 | SRD5A2 (0.47) | MAPTMAPK1ALOX15ALDH1A1RAB9A | |
| SCHEMBL11540613 | 0.80 | MAPT (0.53) | MAPTMAPK1ALOX15ALDH1A1RAB9A | |
| SCHEMBL11539862 | 0.80 | LMNA (0.46) | MAPTMAPK1ALDH1A1RAB9ALMNA | |
| SCHEMBL7412522 | 0.80 | MAPT (0.48) | MAPTMAPK1ALOX15RAB9ALMNA | |
| SCHEMBL11540254 | 0.78 | CYP2C9 (0.58) | MAPTALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL11541053 | 0.78 | MAPT (0.42) | MAPTMAPK1ALDH1A1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166819-A | HYPOTENSIVES, DIURETICS | ABBOTT LABORATORIES (US) | 1979-09-04 | — | — | US | disclosed |
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | disclosed |