Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540256 | 0.88 | MAPT (0.49) | MAPTMAPK1POLBLMNAALOX15 | |
| SCHEMBL11541423 | 0.86 | MAPT (0.59) | MAPTMAPK1LMNAALOX15RAB9A | |
| SCHEMBL11541127 | 0.85 | ALDH1A1 (0.47) | MAPTMAPK1LMNAPARP1NPC1 | |
| SCHEMBL11539862 | 0.84 | LMNA (0.46) | MAPTMAPK1POLBLMNARAB9A | |
| SCHEMBL11543650 | 0.81 | SRD5A2 (0.47) | MAPTMAPK1POLBALOX15NPC1 | |
| SCHEMBL11540728 | 0.81 | CYP2C9 (0.56) | MAPTPOLBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL11540900 | 0.80 | MAPT (0.52) | MAPTMAPK1POLBLMNARAB9A | |
| SCHEMBL11540613 | 0.79 | MAPT (0.53) | MAPTMAPK1POLBLMNAALOX15 | |
| SCHEMBL11541053 | 0.77 | MAPT (0.42) | MAPTMAPK1POLBLMNARAB9A | |
| SCHEMBL11538284 | 0.76 | NPC1 (0.55) | MAPTMAPK1POLBLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166819-A | HYPOTENSIVES, DIURETICS | ABBOTT LABORATORIES (US) | 1979-09-04 | — | — | US | disclosed |
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | disclosed |