Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | CASP3 | P42574 | 1/20 | 0.70 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.70 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.70 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.70 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546656 | 0.88 | NPC1 (0.65) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11646737 | 0.88 | NR4A2 (0.65) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11543626 | 0.87 | NPC1 (0.59) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11544223 | 0.87 | NPC1 (0.53) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11539301 | 0.87 | NPC1 (0.54) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11640352 | 0.87 | DCTPP1 (0.56) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11542745 | 0.85 | NR4A2 (0.67) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11544858 | 0.84 | NPC1 (0.51) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11542430 | 0.83 | NPC1 (0.68) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11640959 | 0.83 | DCTPP1 (0.52) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179566-A | TRANQUILZERS, NEUROLEPTIC AGENTS AND SLEEP INDUCERS | SANDOZ, INC. (US) | 1979-12-18 | — | — | US | disclosed |
| US-4170705-A | Substituted hydroxy pyridones | SANDOZ, INC. (US) | 1979-10-09 | — | — | US | disclosed |
| US-4154928-A | Substituted isoxazolo compounds | SANDOZ, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4122182-A | TRANQUILIZERS, SLEEP INDUCERS, MUSCLE RELAXANTS, NEUROLEPTICS | SANDOZ, INC. (US) | 1978-10-24 | — | — | US | disclosed |
| US-4120967-A | TRANQUILIZERS, SLEEP INDUCERS, NEUROLEPTICS | SANDOX, INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4113727-A | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones | SANDOZ, INC. (US) | 1978-09-12 | — | — | US | disclosed |
| US-4054653-A | TRANQUILIZERS, SLEEP INDUCERS, MUSCLE RELAXANTS | SANDOZ, INC. (US) | 1977-10-18 | — | — | US | disclosed |
| US-4024262-A | TRANQUILIZERS, SLEEP INDUCERS, NEUROLEPTICS | SANDOZ, INC. (US) | 1977-05-17 | — | — | US | disclosed |