Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TPMT | P51580 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | USP10 | Q14694 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546125 | 0.91 | POLB (0.55) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL6534873 | 0.89 | MAPT (0.61) | POLBMAPTVCAM1NPSR1ALDH1A1 | |
| SCHEMBL14882355 | 0.88 | VCAM1 (0.64) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL14879577 | 0.88 | POLB (0.52) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL19294668 | 0.87 | MAPT (0.51) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL573787 | 0.87 | VCAM1 (0.53) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL11542097 | 0.85 | HPSE (0.56) | POLBMAPTXDHNPSR1HPGD | |
| SCHEMBL11542710 | 0.85 | MAPT (0.52) | POLBMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL573529 | 0.85 | VCAM1 (0.51) | POLBMAPTVCAM1XDHNPSR1 | |
| SCHEMBL6136038 | 0.84 | MAPT (0.56) | POLBMAPTVCAM1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116041228-B | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-116041228-A | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-116041228-B | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-116041228-A | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |