Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | USP10 | Q14694 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11850832 | 0.90 | TPMT (0.45) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL14882355 | 0.88 | VCAM1 (0.64) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL573787 | 0.87 | VCAM1 (0.53) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL11540771 | 0.85 | POLB (0.61) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL574029 | 0.84 | VCAM1 (0.46) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL573657 | 0.84 | VCAM1 (0.46) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL10222900 | 0.84 | VCAM1 (0.46) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL573278 | 0.82 | ALDH1A1 (0.48) | MAPTALDH1A1HPGDNPSR1GAA | |
| SCHEMBL11546125 | 0.79 | POLB (0.55) | VCAM1MAPTPOLBALDH1A1HPGD | |
| SCHEMBL573855 | 0.78 | VCAM1 (0.52) | VCAM1MAPTPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |