Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.49 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.49 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540254 | 0.87 | CYP2C9 (0.58) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL11541420 | 0.85 | CYP2C9 (0.65) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL11540728 | 0.85 | CYP2C9 (0.56) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL14419280 | 0.85 | PTGDR2 (0.56) | CYP2C9TSHRLMNATP53MAPT | |
| SCHEMBL11541052 | 0.84 | CYP2C9 (0.57) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL11543646 | 0.81 | CYP2C9 (0.56) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL11541127 | 0.80 | ALDH1A1 (0.47) | TSHRALDH1A1LMNAMAPTHTT | |
| SCHEMBL11540896 | 0.79 | CYP2C9 (0.60) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL11265896 | 0.79 | CYP2C9 (0.54) | CYP2C9TSHRMEN1ABCC3PLIN1 | |
| SCHEMBL10664238 | 0.78 | CYP2C9 (0.60) | CYP2C9TSHRMEN1ABCC3PLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | claimed |
| US-4166819-A | HYPOTENSIVES, DIURETICS | ABBOTT LABORATORIES (US) | 1979-09-04 | — | — | US | disclosed |
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | disclosed |