Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.44 |
| ▸ | HTR7 | P34969 | 6/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11539874 | 0.88 | TSHR (0.44) | MC4RHTR1AHTR7HTR6DRD2 | |
| SCHEMBL11538270 | 0.87 | TSHR (0.47) | MC4RHTR7HTR6MEN1USP2 | |
| SCHEMBL11539715 | 0.84 | HTR2C (0.46) | HTR1AHTR7HTR6HTR2ASLC6A3 | |
| SCHEMBL995182 | 0.74 | L3MBTL1 (0.43) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL9923328 | 0.71 | MC4R (0.72) | MC4RHTR1AHTR1DHTR1BHTT | |
| SCHEMBL9674664 | 0.71 | ALDH1A1 (0.42) | MEN1KMT2AADRA2ASLC6A3KCNH2 | |
| SCHEMBL28416155 | 0.70 | HTR1A (0.43) | MC4RHTR1AHTR7HTR6DRD2 | |
| SCHEMBL11915275 | 0.69 | MCHR1 (0.45) | MEN1KMT2AADRA2ASLC6A3SLC6A2 | |
| SCHEMBL6127471 | 0.68 | TDP1 (0.46) | HTR7HTR6HTR2AHTR1BMEN1 | |
| SCHEMBL10408219 | 0.67 | ALDH1A1 (0.46) | MEN1KMT2AADRA2ASLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170653-A | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers | Ayerst McKenna and Harrison Limited (CA) | 1979-10-09 | — | — | US | disclosed |
| US-4060613-A | ANTIDEPRESSANT | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-11-29 | — | — | US | disclosed |