Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.67 |
| ▸ | SHBG | P04278 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.67 |
| ▸ | PGR | P06401 | 3/20 | 0.67 |
| ▸ | AR | P10275 | 3/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544123 | 1.00 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL601153 | 0.89 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL601152 | 0.89 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL5572178 | 0.89 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL572119 | 0.89 | SHBG (0.77) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL638332 | 0.89 | SHBG (0.77) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL10381565 | 0.88 | CYP3A4 (0.69) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL10381563 | 0.88 | CYP3A4 (0.69) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL8963094 | 0.88 | LMNA (0.66) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL18075707 | 0.86 | SHBG (0.80) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4171358-A | ADMINISTERING PROGESTATIONAL AGENTS | ELI LILLY AND COMPANY (US) | 1979-10-16 | — | — | US | disclosed |
| US-4018919-A | IN MAMMALS | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |