Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.67 |
| ▸ | SHBG | P04278 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.67 |
| ▸ | PGR | P06401 | 3/20 | 0.67 |
| ▸ | AR | P10275 | 3/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL601152 | 1.00 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL5572178 | 1.00 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL11766174 | 0.89 | SHBG (0.64) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL11766184 | 0.89 | SHBG (0.64) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL572119 | 0.89 | SHBG (0.77) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL11544123 | 0.89 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL638332 | 0.89 | SHBG (0.77) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL11544128 | 0.89 | LMNA (0.67) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL9242740 | 0.88 | SHBG (0.63) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 | |
| SCHEMBL8781737 | 0.88 | LMNA (0.69) | LMNASHBGSMN1; SMN2SERPINA6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844333-B1 | Method of treating atherosclerosis | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-01-18 | — | — | US | claimed |
| US-4902681-A | Inhibition of immune clearance using progesterone analogues | UNIVERSITY OF PENNSYLVANIA (US) | 1990-02-20 | — | — | US | claimed |
| US-20150353596-A1 | 17-Substituted Steroid Compounds | HOLLIS-EDEN PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
| EP-1807118-B1 | STEROID ANALOGS AND CHARACTERIZATION AND TREATMENT METHODS | HARBOR BIOSCIENCES INC (US) | 2014-03-12 | — | — | EP | disclosed |
| US-8541600-B2 | 11-aza, 11-thia and 11-oxa sterol compounds and compositions | Harbor Therapeutics, Inc. (US) | 2013-09-24 | — | — | US | disclosed |
| EP-2471536-A1 | STEROID ANALOGS AND CHARACTERIZATION AND TREATMENT METHODS | Harbor BioSciences, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20120101052-A9 | 15-THIA STEROID COMPOUNDS AND COMPOSITIONS | BIOVIE INC. | 2012-04-26 | — | — | US | disclosed |
| US-20120041016-A1 | 11-Aza, 11-Thia and 11-Oxa Sterol Compounds and Compositions | BIOVIE INC. | 2012-02-16 | — | — | US | disclosed |
| US-8022234-B2 | Compounds and compositions | HARBOR BIOSCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20110218162-A1 | 15-THIA STEROID COMPOUNDS AND COMPOSITIONS | FRINCKE JAMES M | 2011-09-08 | — | — | US | disclosed |
| US-7947846-B2 | 15-OXA-steroid compounds | HARBOR BIOSCIENCES, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-4908358-A | Inhibition of immune clearance using progesterone analogues | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1990-03-13 | — | — | US | disclosed |
| US-4902681-A | Inhibition of immune clearance using progesterone analogues | UNIVERSITY OF PENNSYLVANIA (US) | 1990-02-20 | — | — | US | disclosed |
| US-4902681-A | Inhibition of immune clearance using progesterone analogues | UNIVERSITY OF PENNSYLVANIA (US) | 1990-02-20 | — | — | US | disclosed |
| US-4891426-A | EPOXIDATION WITH PERACID | THE UPJOHN COMPANY (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0308412-A1 | 16-g(a)-METHYLATION PROCESS. | UPJOHN CO (US) | 1989-03-29 | — | — | EP | disclosed |
| WO-1987007612-A1 | 16alpha-METHYLATION PROCESS | THE UPJOHN COMPANY (US) | 1987-12-17 | — | — | WO | disclosed |
| US-4704455-A | 16α-methylatedΔ17(20)-corticoids | THE UPJOHN COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0238545-A1 | C 20? THROUGH C 26? AMINO STEROIDS. | UPJOHN CO (US) | 1987-09-30 | — | — | EP | disclosed |
| WO-1987001706-A2 | C20 THROUGH C26 AMINO STEROIDS | THE UPJOHN COMPANY (US) | 1987-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353596-A1 | 17-Substituted Steroid Compounds | HSD3B1, HSD3B2, HSD17B13 | LMNA 3127/4885SHBG 55/4885SMN1; SMN2 3201/4885 |
| US-20120101052-A9 | 15-THIA STEROID COMPOUNDS AND COMPOSITIONS | MPL, THPO, ALOX15 | LMNA 3783/4885SHBG 73/4885SMN1; SMN2 3274/4885 |
| US-20120041016-A1 | 11-Aza, 11-Thia and 11-Oxa Sterol Compounds and Compositions | CYP51A1, HSD11B1, HSD3B1 | LMNA 4455/4885SHBG 105/4885SMN1; SMN2 4528/4885 |
| US-20110218162-A1 | 15-THIA STEROID COMPOUNDS AND COMPOSITIONS | MPL, THPO, ALOX15 | LMNA 3783/4885SHBG 73/4885SMN1; SMN2 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.