Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110805 | 0.85 | GPR119 (0.48) | KMT2AMEN1 | |
| SCHEMBL863473 | 0.82 | KMT2A (0.45) | KMT2AKDM4EALDH1A1HDAC3HDAC4 | |
| SCHEMBL4221454 | 0.80 | ALPG (0.51) | KMT2AKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL23110701 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL31430374 | 0.78 | DRD2 (0.44) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3864362 | 0.76 | GPR119 (0.53) | KMT2AMEN1 | |
| SCHEMBL28549863 | 0.76 | DRD2 (0.43) | — | |
| SCHEMBL20616624 | 0.74 | KMT2A (0.73) | KMT2AKDM4EALDH1A1HDAC3HDAC4 | |
| SCHEMBL23093804 | 0.74 | CCR1 (0.38) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL20616667 | 0.73 | TRPM8 (0.59) | KMT2AKDM4EALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166119-A | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines | AMERICAN HOECHST CORPORATION (US) | 1979-08-28 | — | — | US | disclosed |