Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534866 | 0.87 | CA1 (0.58) | USP2ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL2875469 | 0.86 | HPGD (0.52) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL14879772 | 0.86 | USP2 (0.45) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL14879659 | 0.86 | ALDH1A1 (0.51) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL11546125 | 0.85 | POLB (0.55) | USP2ALDH1A1HPGDMAPTLMNA | |
| SCHEMBL16577888 | 0.85 | USP2 (0.44) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL11546751 | 0.84 | ALDH1A1 (0.49) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL573278 | 0.83 | ALDH1A1 (0.48) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL11543235 | 0.83 | KDM4E (0.58) | USP2TSHRALDH1A1HPGDKDM4E | |
| SCHEMBL11544248 | 0.82 | KMT2A (0.45) | USP2TSHRALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116041228-B | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-116041228-A | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-116041228-B | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-116041228-A | Synthesis method of bumetanide | 沈阳希贝康医药科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |