Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | ACLY | P53396 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11849419 | 0.90 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL2875469 | 0.88 | HPGD (0.52) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL14879659 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL573278 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL11545452 | 0.84 | USP2 (0.54) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL11546591 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4EGAAUSP2 | |
| SCHEMBL574175 | 0.79 | HPGD (0.43) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL573731 | 0.79 | HPGD (0.43) | ALDH1A1HPGDKDM4EGAAPKM | |
| SCHEMBL11550368 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EUSP2ACLY | |
| SCHEMBL11847444 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |