Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545452 | 0.86 | USP2 (0.54) | USP2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14879577 | 0.81 | POLB (0.52) | NOTUMALDH1A1HPGDMAPTPOLB | |
| SCHEMBL14879713 | 0.78 | RAB9A (0.50) | USP2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14881379 | 0.78 | KDM4E (0.56) | USP2NOTUMALDH1A1KDM4EHPGD | |
| SCHEMBL8075068 | 0.77 | NOTUM (0.54) | USP2NOTUMALDH1A1KDM4EGAA | |
| SCHEMBL14879659 | 0.77 | ALDH1A1 (0.51) | USP2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL2875469 | 0.77 | HPGD (0.52) | USP2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14879718 | 0.76 | IDO1 (0.40) | USP2NOTUMALDH1A1KDM4EHPGD | |
| SCHEMBL27901095 | 0.76 | NOTUM (0.51) | USP2NOTUMALDH1A1KDM4EGAA | |
| SCHEMBL11546125 | 0.76 | POLB (0.55) | USP2ALDH1A1HPGDMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059648-A1 | 2,3,5 TRISUBSTITUTED ARYL AND HETEROARYL AMINO DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2013059648-A1 | 2,3,5 TRISUBSTITUTED ARYL AND HETEROARYL AMINO DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |