Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 2/20 | 0.37 |
| ▸ | CMA1 | P23946 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543053 | 0.88 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11543213 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11546591 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11543216 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11544248 | 0.81 | KMT2A (0.45) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11544815 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11547865 | 0.79 | LMNA (0.46) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11546751 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11544617 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL16577889 | 0.78 | KMT2A (0.42) | ALDH1A1KDM4ELMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |