Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548819 | 0.89 | ELANE (0.46) | ELANEKMT2AMAPTMEN1RAB9A | |
| SCHEMBL11552101 | 0.87 | LMNA (0.41) | KMT2ASMN1; SMN2ESR1RECQLMAPT | |
| SCHEMBL11547801 | 0.85 | CNR2 (0.47) | KMT2ASMN1; SMN2MAPTMEN1TP53 | |
| SCHEMBL11551463 | 0.85 | CNR2 (0.47) | KMT2ASMN1; SMN2MAPTMEN1TP53 | |
| SCHEMBL11547391 | 0.85 | ABCG2 (0.43) | KMT2AESR1MEN1CYP2C9 | |
| SCHEMBL11552089 | 0.85 | LMNA (0.47) | KMT2AESR1MAPTMEN1HTT | |
| SCHEMBL11547513 | 0.84 | ELANE (0.40) | ELANEKMT2ASMN1; SMN2ESR1HIF1A | |
| SCHEMBL11551236 | 0.83 | ELANE (0.39) | ELANEKMT2AESR1MAPTMEN1 | |
| SCHEMBL11549453 | 0.83 | ELANE (0.39) | ELANEKMT2AESR1MAPTMEN1 | |
| SCHEMBL11547002 | 0.82 | ESR1 (0.47) | KMT2AESR1HIF1AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4133814-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |