Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | GRK3 | P35626 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545627 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1ABCB1GRK3ADRB1 | |
| SCHEMBL11549323 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1ABCB1GRK3ADRB1 | |
| SCHEMBL11546112 | 0.80 | ADRB2 (0.52) | KDM4EALDH1A1GRK3ADRB1ADRB2 | |
| SCHEMBL11549703 | 0.80 | ADRB2 (0.55) | KDM4EABCB1GRK3ADRB1ADRB2 | |
| SCHEMBL11550951 | 0.79 | KDM4E (0.52) | KDM4EALDH1A1ABCB1GRK3ADRB1 | |
| SCHEMBL11548789 | 0.77 | GRK3 (0.54) | KDM4EALDH1A1GRK3ADRB1ADRB2 | |
| SCHEMBL11545703 | 0.77 | ADRB1 (0.45) | GRK3ADRB1ADRB2ADRB3KMT2A | |
| SCHEMBL10742969 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1GRK3ADRB1ADRB2 | |
| Tolamolol SCHEMBL611643 | 0.76 | ATM (0.59) | KDM4EALDH1A1ABCB1ADRB1ADRB2 | |
| Tolamolol SCHEMBL613511 | 0.76 | ATM (0.59) | KDM4EALDH1A1ABCB1ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | claimed |
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |