Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | GRK3 | P35626 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11549703 | 0.89 | ADRB2 (0.55) | ADRB1ADRB3ADRB2GRK3MEN1 | |
| SCHEMBL11545627 | 0.88 | KDM4E (0.53) | ADRB1ADRB3ADRB2GRK3MEN1 | |
| SCHEMBL11545309 | 0.85 | ADRB1 (0.58) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL11543785 | 0.85 | ADRB2 (0.56) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL11549323 | 0.85 | KDM4E (0.49) | ADRB1ADRB3ADRB2GRK3KMT2A | |
| SCHEMBL11546599 | 0.85 | ADRB2 (0.47) | ADRB1ADRB3ADRB2GRK3MEN1 | |
| SCHEMBL7410486 | 0.82 | ADRB2 (0.54) | ADRB1ADRB3ADRB2GRK3KMT2A | |
| SCHEMBL11546769 | 0.81 | ADRB3 (0.51) | ADRB1ADRB3ADRB2 | |
| SCHEMBL11545485 | 0.80 | ADRB2 (0.51) | ADRB1ADRB3ADRB2GRK3MEN1 | |
| SCHEMBL10744537 | 0.79 | KMT2A (0.46) | ADRB1ADRB3ADRB2GRK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | claimed |
| US-4165384-A | ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS | AKTIEBOLAGET HASSLE (SE) | 1979-08-21 | — | — | US | disclosed |
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |