Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743261 | 0.86 | HSD17B10 (0.69) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10084487 | 0.84 | HSD17B10 (0.55) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL24802486 | 0.81 | HSD17B10 (0.53) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8199577 | 0.80 | ALDH1A1 (0.57) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1218749 | 0.76 | HSD17B10 (1.00) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31529600 | 0.76 | HSD17B10 (1.00) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14684396 | 0.72 | HSD17B10 (0.48) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11124552 | 0.72 | HSD17B10 (0.67) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3558037 | 0.72 | KDM4E (0.66) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11546086 | 0.72 | KDM4E (1.00) | HSD17B10KDM4EMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4044134-A | FUSED WITH QUINOLINE OR PYRIDINE, 2-METHYL, ETHYL, OR ACETYL GROUP | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |