Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 9/20 | 0.35 |
| ▸ | CA1 | P00915 | 8/20 | 0.35 |
| ▸ | CA9 | Q16790 | 6/20 | 0.35 |
| ▸ | CA12 | O43570 | 6/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 4/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.35 |
| ▸ | CA6 | P23280 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546144 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11545196 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11548825 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11548139 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11544995 | 0.79 | LMNA (0.73) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11541774 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11545593 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11544741 | 0.75 | KDM4E (0.53) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11542435 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL11543884 | 0.73 | KDM4E (0.61) | KDM4EALDH1A1USP2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |