Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 16/20 | 0.53 |
| ▸ | GRK3 | P35626 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545627 | 0.84 | KDM4E (0.53) | ADRB1ADRB2ADRB3GRK3 | |
| SCHEMBL11549323 | 0.83 | KDM4E (0.49) | ADRB1ADRB2ADRB3GRK3 | |
| SCHEMBL10892720 | 0.79 | GRK3 (0.49) | ADRB1ADRB2ADRB3GRK3 | |
| Hydrochloric Acid SCHEMBL10888073 | 0.78 | GRK3 (0.49) | ADRB1ADRB2ADRB3GRK3 | |
| SCHEMBL11545404 | 0.78 | ADRB3 (0.41) | ADRB1ADRB2ADRB3 | |
| SCHEMBL10889364 | 0.78 | GRK3 (0.50) | ADRB1ADRB2ADRB3GRK3 | |
| SCHEMBL11549703 | 0.75 | ADRB2 (0.55) | ADRB1ADRB2ADRB3GRK3 | |
| SCHEMBL10810577 | 0.75 | ADRB2 (0.60) | ADRB1ADRB2ADRB3 | |
| SCHEMBL11548953 | 0.75 | OPRM1 (0.58) | — | |
| SCHEMBL11550951 | 0.74 | KDM4E (0.52) | ADRB1ADRB2ADRB3GRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | claimed |
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |