Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5710105 | 0.85 | ALOX5 (0.57) | NPC1JAK2RAB9APAX8PTGES | |
| SCHEMBL2849795 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL1204768 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL60682 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL619876 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL7924615 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL166835 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL44732 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL985190 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A | |
| SCHEMBL45379 | 0.80 | NPC1 (0.53) | NPC1JAK2RAB9APAX8MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |