Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 7/20 | 0.64 |
| ▸ | EYA3 | Q99504 | 6/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.64 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.64 |
| ▸ | TTR | P02766 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | PGR | P06401 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | EYA2 | O00167 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556111 | 0.88 | CYP2C19 (0.60) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| SCHEMBL11555712 | 0.85 | EYA3 (0.55) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| SCHEMBL11555575 | 0.85 | CYP2C19 (0.62) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| SCHEMBL1287583 | 0.83 | CYP2C19 (0.77) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| SCHEMBL11552492 | 0.79 | EYA3 (0.52) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| Benzbromarone SCHEMBL48993 | 0.78 | SLC22A12 (1.00) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| SCHEMBL18058593 | 0.78 | CYP2C19 (0.81) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| Benzbromarone SCHEMBL29361528 | 0.78 | SLC22A12 (1.00) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| Benzbromarone SCHEMBL19205474 | 0.78 | SLC22A12 (1.00) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 | |
| Hydrochloric Acid SCHEMBL10615321 | 0.78 | EYA3 (0.64) | CYP2C19EYA3CYP2C9SLC22A12NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |