Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 8/20 | 0.62 |
| ▸ | EYA3 | Q99504 | 5/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | EYA2 | O00167 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556449 | 0.87 | EYA3 (0.58) | CYP2C19EYA3CYP2C9THRBTHRA | |
| SCHEMBL11559523 | 0.85 | CYP2C19 (0.64) | CYP2C19EYA3CYP2C9THRBMEN1 | |
| SCHEMBL11551818 | 0.84 | EYA3 (0.55) | CYP2C19EYA3CYP2C9THRBTHRA | |
| SCHEMBL11555043 | 0.78 | CYP2C19 (0.56) | CYP2C19EYA3CYP2C9THRBTHRA | |
| SCHEMBL28245013 | 0.77 | CYP2C19 (0.75) | CYP2C19EYA3CYP2C9THRBTHRA | |
| SCHEMBL11554465 | 0.77 | MAOB (0.46) | MEN1KMT2ALMNAMAPTCA12 | |
| SCHEMBL11558589 | 0.77 | ALDH1A1 (0.47) | CYP2C19MEN1KMT2ALMNAUSP2 | |
| SCHEMBL11552578 | 0.76 | STK17B (0.63) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL11552685 | 0.76 | NR4A2 (0.46) | CYP2C19CYP2C9MEN1KMT2ALMNA | |
| SCHEMBL11553411 | 0.76 | CNR2 (0.40) | CYP2C9LMNAMAPK1HSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |