Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11564817 | 0.82 | PDE9A (0.46) | PDE9APDE1CALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11568936 | 0.78 | PDE9A (0.46) | PDE9APDE1CALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11564514 | 0.77 | HSD11B1 (0.56) | PDE9AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11560285 | 0.76 | ALDH1A1 (0.47) | PDE9APDE1CALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11586131 | 0.74 | KEAP1 (0.41) | PDE9APDE1CALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11585656 | 0.72 | KEAP1 (0.42) | ALDH1A1HTTKDM4EATMIDO1 | |
| SCHEMBL11564415 | 0.72 | USP8 (0.42) | PDE9AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4277182 | 0.71 | PDE9A (0.51) | PDE9APDE1CALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5186477 | 0.70 | PDE9A (0.47) | PDE9APDE1CALDH1A1HTTKDM4E | |
| SCHEMBL295307 | 0.69 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2C9CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4180666-A | 3,9-Dihydro-3,9-dioxo-2H-indeno(2,1-c)-pyridine-4-(carbonitriles/carboxamides) | G. D. SEARLE & CO. (US) | 1979-12-25 | — | — | US | disclosed |