Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658098 | 0.84 | ESR2 (0.42) | HTR7GPBAR1ADORA2ATP53ALDH1A1 | |
| SCHEMBL10662388 | 0.81 | RPS6KB1 (0.44) | HTR7GPBAR1CYP17A1CYP1A1CYP1A2 | |
| SCHEMBL10734889 | 0.80 | HTR7 (0.45) | HTR7GPBAR1GABRA5GABRPGABRD | |
| SCHEMBL11558638 | 0.80 | MAPK14 (0.37) | GABRA5 | |
| SCHEMBL11560540 | 0.80 | PTGS1 (0.33) | GABRA5CYP17A1THRB | |
| SCHEMBL11560465 | 0.79 | PTGS1 (0.36) | GPBAR1ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL11559332 | 0.79 | ESR1 (0.42) | ALDH1A1HTTCYP1B1NOTUM | |
| SCHEMBL11557734 | 0.77 | HTR2A (0.39) | HTR7GPBAR1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL10655770 | 0.77 | PTGER2 (0.50) | — | |
| SCHEMBL11563201 | 0.77 | PTGS1 (0.38) | HTR7GPBAR1GABRA5CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |