Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11563201 | 0.86 | PTGS1 (0.38) | PTGS1GPBAR1MAPT | |
| SCHEMBL11558673 | 0.85 | PTGS1 (0.45) | PTGS1NPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10662606 | 0.82 | LMNA (0.40) | PTGS1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL11553949 | 0.82 | PTGS1 (0.32) | PTGS1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL11560703 | 0.79 | HTR7 (0.41) | KMT2AGPBAR1HTTMEN1ALDH1A1 | |
| SCHEMBL10665157 | 0.79 | HTR3A (0.41) | PTGS1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL11558638 | 0.77 | MAPK14 (0.37) | MAPTPOLBHTR5A | |
| SCHEMBL11558263 | 0.77 | GABRA5 (0.35) | PTGS1GPBAR1ALDH1A1 | |
| SCHEMBL11560540 | 0.77 | PTGS1 (0.33) | PTGS1NPC1RAB9A | |
| SCHEMBL11557764 | 0.77 | ESR1 (0.40) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |