Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913153 | 0.76 | TYMP (0.51) | TSHRRAB9AL3MBTL1KDM4ELMNA | |
| SCHEMBL31009220 | 0.76 | — | — | |
| SCHEMBL14491 | 0.74 | TYMP (0.49) | TSHRRAB9APKMTYMPSIGMAR1 | |
| SCHEMBL11728159 | 0.74 | MAPT (0.46) | TSHRRAB9AKDM4EPKMP2RX4 | |
| SCHEMBL3015728 | 0.68 | TYMP (0.54) | TSHRRAB9ATYMPSIGMAR1GSK3A | |
| SCHEMBL27636345 | 0.67 | L3MBTL1 (0.47) | TSHRRAB9AL3MBTL1KDM4ELMNA | |
| SCHEMBL1418006 | 0.66 | TK1 (0.49) | TYMPHPGDDAO | |
| SCHEMBL13341564 | 0.66 | TSHR (0.46) | TSHRRAB9AL3MBTL1KDM4ELMNA | |
| SCHEMBL31621004 | 0.65 | TYMP (0.60) | TSHRRAB9ATYMPSIGMAR1GSK3A | |
| SCHEMBL11792243 | 0.65 | P2RX4 (0.59) | TSHRRAB9AL3MBTL1TYMPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102140095-A | Green new process for preparing tizanidine hydrochloride | CHANGZHOU YABANG PHARMACEUTICAL CO LTD | 2011-08-03 | — | — | CN | disclosed |
| US-4168381-A | Enhancement of enantioselectivity by iodide salts of Rh(I) complexes in the reduction of prochiral imidazolinones | AMERICAN CYANAMID COMPANY (US) | 1979-09-18 | — | — | US | disclosed |