Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872108 | 0.81 | MAOB (0.51) | LMNAHPGDMAOBCHEK1AKT2 | |
| SCHEMBL1937534 | 0.78 | ADORA2A (0.43) | HPGDALDH1A1KDM4EMAOBGLA | |
| SCHEMBL2872995 | 0.77 | NPC1 (0.48) | LMNAHPGDALDH1A1KDM4EGLA | |
| SCHEMBL10131893 | 0.74 | MAOB (0.45) | LMNAHPGDMAOBCHEK1AKT2 | |
| SCHEMBL12306078 | 0.74 | LMNA (0.47) | LMNAHPGDKDM4EMAOBCHEK1 | |
| SCHEMBL2865128 | 0.74 | LMNA (0.41) | LMNAKDM4ECHEK1AKT2BRD4 | |
| SCHEMBL26287757 | 0.71 | MEN1 (0.32) | — | |
| SCHEMBL10015953 | 0.70 | MAOB (0.42) | LMNAHPGDALDH1A1KDM4EMAOB | |
| SCHEMBL2872817 | 0.70 | MAOB (0.60) | LMNAHPGDALDH1A1MAOBCHEK1 | |
| SCHEMBL12181771 | 0.70 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4169158-A | Pyridazine derivatives in alleviating depressive states | CENTRE D'ETUDES EXPERIMENTALES ET CLINIQUES DE PHYSIO BIOLOGIE DE PHARMACOLOGIE ET D'EUTONOLOGIE (FR) | 1979-09-25 | — | — | US | disclosed |