Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872108 | 0.86 | MAOB (0.51) | NPC1RAB9ALMNAHTTCYP1A2 | |
| SCHEMBL2865128 | 0.86 | LMNA (0.41) | NPC1RAB9AMAPK1LMNAHTT | |
| SCHEMBL3018231 | 0.79 | KDM4E (0.43) | MAPK1LMNAHTTCYP1A2MAPT | |
| SCHEMBL1898825 | 0.79 | LMNA (0.47) | NPC1RAB9AMAPK1LMNAHTT | |
| SCHEMBL528504 | 0.79 | GABRA1 (0.39) | NPC1RAB9AMAPK1LMNAHTT | |
| SCHEMBL28576050 | 0.79 | KDM4E (0.44) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL12306078 | 0.78 | LMNA (0.47) | NPC1RAB9ALMNAHTTCYP1A2 | |
| SCHEMBL10131893 | 0.78 | MAOB (0.45) | NPC1RAB9ALMNAHTTCYP1A2 | |
| SCHEMBL3561069 | 0.77 | LMNA (0.47) | NPC1RAB9AMAPK1LMNACYP1A2 | |
| SCHEMBL3257778 | 0.76 | PDE4A (0.46) | LMNAHTTCYP1A2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130359-A1 | Fungicidal Pyridazines, Processes for Their Preparation and Their Use for Controlling Harmful Fungi, and Compositions Comprising Them | BASF SE (DE) | 2010-05-27 | — | — | US | disclosed |
| US-20100022526-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-28 | — | — | US | disclosed |
| EP-2121628-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | Syngenta Participations AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| EP-2064188-A1 | FUNGICIDAL PYRIDAZINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR CONTROLLING FUNGI AND AGENTS CONTAINING THE SAME | BASF SE (DE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008135413-A1 | FUNGICIDAL PYRIDAZINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR CONTROLLING FUNGI AND AGENTS CONTAINING THE SAME | BASF SE (DE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008089934-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130359-A1 | Fungicidal Pyridazines, Processes for Their Preparation and Their Use for Controlling Harmful Fungi, and Compositions Comprising Them | PNPO, CYP4Z1, CYP3A5 | NPC1 3477/4885RAB9A 3804/4885MAPK1 1012/4885 |
| US-20100022526-A1 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | CYP4Z1, CYP1A2, CYP1A1 | NPC1 3839/4885RAB9A 2942/4885MAPK1 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.