Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560456 | 0.91 | HCAR3 (0.61) | HCAR3CXCR1CXCR2SRD5A2TAS2R14 | |
| SCHEMBL11565561 | 0.90 | HCAR3 (0.66) | HCAR3CXCR1CXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11564050 | 0.85 | LMNA (0.43) | HCAR3CXCR1CXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11565320 | 0.82 | HCAR3 (0.64) | HCAR3CXCR1CXCR2TAS2R14SMN1; SMN2 | |
| SCHEMBL16127982 | 0.82 | HCAR3 (0.50) | HCAR3CXCR1CXCR2TAS2R14ALDH1A1 | |
| SCHEMBL11567282 | 0.82 | GAA (0.49) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL19618245 | 0.80 | HCAR3 (0.51) | HCAR3CXCR1CXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11561152 | 0.80 | TDP1 (0.49) | HCAR3CXCR1CXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL17570335 | 0.79 | HCAR3 (0.47) | HCAR3CXCR1CXCR2TAS2R14SMN1; SMN2 | |
| SCHEMBL11568099 | 0.79 | KDM4E (0.41) | CXCR1CXCR2ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000816-A1 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-02-21 | — | — | EP | claimed |
| EP-0000816-A1 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-02-21 | — | — | EP | disclosed |