SCHEMBL11565133

SCHEMBL11565133

O=c1sc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2s1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
GPR35 Q9HC97 5/20 0.42
TDP1 Q9NUW8 4/20 0.42
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
HPGD P15428 3/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 2/20 0.42
ALOX12 P18054 2/20 0.42
MAPK1 P28482 2/20 0.42
HIF1A Q16665 2/20 0.42
TTR P02766 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
ALOX15 P16050 1/20 0.42
RECQL P46063 1/20 0.42
PMP22 Q01453 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CYP3A4 P08684 1/20 0.41
TXNRD1 Q16881 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11541724 0.81 TSHR (0.38) ALDH1A1GPR35TDP1KMT2AMEN1
SCHEMBL11563450 0.81 PLK1 (0.38) ALDH1A1TDP1HPGDMAPTHIF1A
SCHEMBL11537061 0.78 PLK1 (0.56) ALDH1A1TDP1HPGDKDM4EMAPT
SCHEMBL11563370 0.77 ALDH1A1 (0.39) ALDH1A1TDP1KMT2AMEN1HPGD
SCHEMBL11565055 0.77 VCAM1 (0.51) TDP1HPGDMAPTMAPK1CYP1A2
SCHEMBL11539878 0.73 TDP1 (0.45) ALDH1A1GPR35TDP1KMT2AMEN1
SCHEMBL15153601 0.73 ALDH1A1 (0.49) ALDH1A1GPR35TDP1KMT2AMEN1
SCHEMBL11502495 0.72 MPI (0.41) ALDH1A1GPR35TDP1KMT2AMEN1
SCHEMBL11563997 0.72 CRHBP (0.50) ALDH1A1TDP1HSD17B10CYP3A4TXNRD1
SCHEMBL9806034 0.69 ALDH1A1 (0.46) ALDH1A1GPR35TDP1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4175186-A CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID THE ANSUL COMPANY (US) 1979-11-20 US claimed
US-4084954-A HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES THE ANSUL COMPANY (US) 1978-04-18 US claimed
US-4177270-A Soil fungicidal (nitrogen heterocyclic)-substituted-1,3-benzodithiole-2-ones THE ANSUL COMPANY (US) 1979-12-04 US disclosed
US-4175186-A CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID THE ANSUL COMPANY (US) 1979-11-20 US disclosed
US-4084954-A HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES THE ANSUL COMPANY (US) 1978-04-18 US disclosed