Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11566764 | 0.86 | AKR1B1 (0.39) | AKR1B1MAPK14ALDH1A1RAB9AMEN1 | |
| SCHEMBL11564672 | 0.84 | HTT (0.41) | AKR1B1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL8880119 | 0.81 | AKR1B1 (0.66) | AKR1B1MAPK14ACHEMEN1HTT | |
| SCHEMBL11832932 | 0.80 | AKR1B1 (0.53) | AKR1B1MAPK14ACHEALDH1A1TTR | |
| SCHEMBL11569877 | 0.80 | AKR1B1 (0.61) | AKR1B1MAPK14ACHEALDH1A1RAB9A | |
| SCHEMBL11663201 | 0.80 | AKR1B1 (0.61) | AKR1B1MAPK14ACHEALDH1A1RAB9A | |
| SCHEMBL11754579 | 0.77 | AKR1B1 (0.60) | AKR1B1MAPK14ACHEMITFHSP90AA1 | |
| SCHEMBL11566471 | 0.77 | AKR1B1 (0.60) | AKR1B1MAPK14ACHEALDH1A1HIF1A | |
| SCHEMBL2007673 | 0.77 | AKR1B1 (0.57) | AKR1B1MAPK14ALDH1A1 | |
| SCHEMBL11562156 | 0.75 | AKR1B1 (0.65) | AKR1B1MAPK14ALDH1A1RAB9AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003422-A1 | Novel 4-(8X-6,11-dihydrodibenzo-(b,e)-thiepin-11-one-3-yl)-4-oxobutyric acids, methods of preparation, compositions and uses thereof | SYNTEX (U.S.A.) INC. (US) | 1979-08-08 | — | — | EP | disclosed |
| US-4130654-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, FRIBRINOLYTIC, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1978-12-19 | — | — | US | disclosed |
| US-4000308-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000288-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, PYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |