Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880119 | 0.87 | AKR1B1 (0.66) | AKR1B1MAPK14ACHETTRNOTUM | |
| SCHEMBL11663201 | 0.86 | AKR1B1 (0.61) | AKR1B1MAPK14ACHETTRMAOA | |
| SCHEMBL11566471 | 0.85 | AKR1B1 (0.60) | AKR1B1MAPK14ACHETTRMAOA | |
| SCHEMBL11566981 | 0.85 | AKR1B1 (0.44) | AKR1B1MAPK14SRD5A2SRD5A1NPC1 | |
| SCHEMBL2007673 | 0.83 | AKR1B1 (0.57) | AKR1B1MAPK14PTPRCALDH1A1L3MBTL1 | |
| SCHEMBL11754579 | 0.83 | AKR1B1 (0.60) | AKR1B1MAPK14ACHETTRMAOA | |
| SCHEMBL11564656 | 0.82 | KDM4E (0.46) | AKR1B1MAOAHSD17B3 | |
| SCHEMBL11562156 | 0.81 | AKR1B1 (0.65) | AKR1B1MAPK14TTRSRD5A2ALDH1A1 | |
| SCHEMBL11763424 | 0.80 | AKR1B1 (0.79) | AKR1B1MAPK14ACHENOTUM | |
| SCHEMBL11565479 | 0.80 | AKR1B1 (0.54) | AKR1B1MAPK14ACHETTRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003422-A1 | Novel 4-(8X-6,11-dihydrodibenzo-(b,e)-thiepin-11-one-3-yl)-4-oxobutyric acids, methods of preparation, compositions and uses thereof | SYNTEX (U.S.A.) INC. (US) | 1979-08-08 | — | — | EP | disclosed |
| US-4130654-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, FRIBRINOLYTIC, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1978-12-19 | — | — | US | disclosed |
| US-4000308-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000288-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, PYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |