Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | TTR | P02766 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.51 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11569877 | 0.87 | AKR1B1 (0.61) | AKR1B1TTRMAPK14SRD5A2SRD5A1 | |
| SCHEMBL11663201 | 0.87 | AKR1B1 (0.61) | AKR1B1TTRMAPK14NOTUMKMT2A | |
| SCHEMBL11754579 | 0.87 | AKR1B1 (0.60) | AKR1B1TTRMAPK14SRD5A2SRD5A1 | |
| SCHEMBL86351 | 0.86 | TTR (0.55) | AKR1B1TTRSRD5A2SRD5A1PTPRC | |
| SCHEMBL11562156 | 0.84 | AKR1B1 (0.65) | AKR1B1TTRMAPK14SRD5A2LMNA | |
| SCHEMBL2007673 | 0.84 | AKR1B1 (0.57) | AKR1B1MAPK14PTPRCPOLBLMNA | |
| SCHEMBL11566471 | 0.84 | AKR1B1 (0.60) | AKR1B1TTRMAPK14SRD5A2SRD5A1 | |
| SCHEMBL11658676 | 0.83 | SRD5A2 (0.55) | AKR1B1TTRSRD5A2SRD5A1PTPRC | |
| SCHEMBL11565479 | 0.81 | AKR1B1 (0.54) | AKR1B1TTRMAPK14SRD5A2SRD5A1 | |
| SCHEMBL11567137 | 0.80 | AKR1B1 (0.56) | AKR1B1TTRMAPK14SRD5A2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607955-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |