SCHEMBL11568366

SCHEMBL11568366

COc1ccc(NC2(C(=O)O)CCN(Cc3ccccc3)CC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.58
TSHR P16473 1/20 0.58
FAAH O00519 3/20 0.58
SIGMAR1 Q99720 2/20 0.57
MMP1 P03956 2/20 0.56
MMP9 P14780 2/20 0.56
MMP13 P45452 2/20 0.56
ADAM17 P78536 2/20 0.56
ACHE P22303 2/20 0.56
BACE1 P56817 1/20 0.56
ALDH1A1 P00352 3/20 0.55
MAPT P10636 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
POLB P06746 1/20 0.53
HSD17B10 Q99714 1/20 0.52
CTSK P43235 1/20 0.51
OPRM1 P35372 1/20 0.51
OPRD1 P41143 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11559495 0.92 CYP2D6 (0.57) CYP2D6TSHRFAAHSIGMAR1MMP1
SCHEMBL8893210 0.91 ALDH1A1 (0.61) CYP2D6TSHRFAAHSIGMAR1MMP1
SCHEMBL11562600 0.87 NPFFR1 (0.61) TSHRFAAHSIGMAR1ALDH1A1MAPT
SCHEMBL2985624 0.87 NPFFR1 (0.62) CYP2D6TSHRFAAHALDH1A1MAPT
SCHEMBL11567112 0.86 FAAH (0.55) CYP2D6FAAHALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL5240984 0.86 NPFFR1 (0.61) CYP2D6TSHRFAAHALDH1A1MAPT
SCHEMBL6045494 0.86 NPFFR1 (0.61) CYP2D6TSHRFAAHALDH1A1MAPT
Hydrochloric Acid SCHEMBL11455282 0.86 NPFFR1 (0.61) CYP2D6TSHRFAAHALDH1A1MAPT
SCHEMBL11566176 0.84 FAAH (0.55) CYP2D6FAAHSIGMAR1ALDH1A1L3MBTL1
SCHEMBL3171094 0.83 NPFFR1 (0.60) CYP2D6TSHRFAAHALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4179569-A ANALGESIC INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1979-12-18 US disclosed
US-3998834-A ANALGESICS JANSSEN PHARMACEUTICA N.V. (BE) 1976-12-21 US disclosed