Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL28154438 | 0.86 | MMP8 (0.46) | MMP8MMP1MMP2GRM2EPHX1 | |
| Cadaverine Tartrate SCHEMBL2998062 | 0.84 | TSHR (0.48) | TP53MMP8MMP1MMP2GRM2 | |
| Cyclohexylamine SCHEMBL4064700 | 0.83 | MMP8 (0.44) | TP53MMP8MMP1MMP2ALDH1A1 | |
| Cyclohexylamine SCHEMBL9082115 | 0.83 | MMP8 (0.44) | MMP8MMP1MMP2GRM2EPHX1 | |
| Valine SCHEMBL28257081 | 0.81 | SLC7A5 (0.60) | MMP8MMP1MMP2GRM2ALDH1A1 | |
| Valine SCHEMBL8706964 | 0.81 | SLC7A5 (0.60) | MMP8MMP1MMP2GRM2ALDH1A1 | |
| Cyclohexylamine SCHEMBL27738388 | 0.80 | MMP8 (0.43) | MMP8MMP1MMP2EPHX1ALDH1A1 | |
| Cyclohexylamine SCHEMBL27242018 | 0.80 | MMP8 (0.43) | MMP8MMP1MMP2EPHX1ALDH1A1 | |
| Cyclohexylamine SCHEMBL1427270 | 0.80 | MMP8 (0.43) | MMP8MMP1MMP2EPHX1ALDH1A1 | |
| Cyclohexylamine SCHEMBL578785 | 0.80 | CES2 (0.43) | MMP8MMP1MMP2EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144159-A | POLYGLYCIDYL ETHERS OF POLYPHENOLS, CHAIN EXTENSION, SALT FORMATION, QUATERNIZATION | PPG INDUSTRIES, INC. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4115226-A | FOR COATING FERROUS METALS | PPG INDUSTRIES, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4110287-A | Cataphoretic N-heterocyclic-containing resins for electrodeposition | PPG INDUSTRIES, INC. (US) | 1978-08-29 | — | — | US | disclosed |
| US-4081343-A | CATIONIC POLYAMINE RESIN, PIGMENT PASTE | PPG INDUSTRIES, INC. (US) | 1978-03-28 | — | — | US | disclosed |