SCHEMBL11566633

SCHEMBL11566633

COCC1(Nc2ccccc2)CCN(CCc2cccn2C)CC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPFFR1 Q9GZQ6 6/20 0.45
NPFFR2 Q9Y5X5 6/20 0.45
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 1/20 0.38
RAB9A P51151 1/20 0.38
CA12 O43570 5/20 0.38
CA1 P00915 5/20 0.38
CA2 P00918 5/20 0.38
CA4 P22748 5/20 0.38
CA5A P35218 5/20 0.38
CA7 P43166 5/20 0.38
CA9 Q16790 5/20 0.38
CA13 Q8N1Q1 5/20 0.38
CA14 Q9ULX7 5/20 0.38
OPRM1 P35372 2/20 0.37
OPRD1 P41143 1/20 0.37
OPRK1 P41145 1/20 0.37
CYP3A4 P08684 2/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9148987 0.84 NPFFR1 (0.61) NPFFR1NPFFR2SMN1; SMN2CA12CA1
Hydrochloric Acid SCHEMBL11565432 0.83 NPFFR1 (0.60) NPFFR1NPFFR2SMN1; SMN2CA12CA1
SCHEMBL11564641 0.82 NPFFR1 (0.53) NPFFR1NPFFR2SMN1; SMN2SIGMAR1
SCHEMBL11569035 0.82 DRD2 (0.46) NPFFR1NPFFR2OPRM1SIGMAR1
SCHEMBL11566101 0.80 SIGMAR1 (0.46) NPFFR1NPFFR2OPRM1SIGMAR1
SCHEMBL11566366 0.80 CA12 (0.49) NPFFR1NPFFR2SMN1; SMN2ALDH1A1RAB9A
SCHEMBL11568672 0.79 NPFFR1 (0.44) NPFFR1NPFFR2SMN1; SMN2RAB9AOPRK1
SCHEMBL11566486 0.79 SIGMAR1 (0.55) NPFFR1NPFFR2SMN1; SMN2OPRM1OPRD1
SCHEMBL11566955 0.79 NPFFR1 (0.53) NPFFR1NPFFR2SMN1; SMN2CA12CA1
SCHEMBL11566208 0.79 NPFFR1 (0.45) NPFFR1NPFFR2SMN1; SMN2CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4179569-A ANALGESIC INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1979-12-18 US disclosed