Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RARB | P10826 | 6/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.44 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL2061236 | 1.00 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Terephthalic Acid SCHEMBL8439003 | 1.00 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Terephthalic Acid SCHEMBL11767757 | 0.94 | ALDH1A1 (0.48) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Paraben SCHEMBL27660431 | 0.92 | CA12 (0.59) | ALDH1A1TP53TSHRSRD5A2CA12 | |
| Terephthalic Acid SCHEMBL28695936 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Terephthalic Acid SCHEMBL28768369 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Terephthalic Acid SCHEMBL2420235 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRSMN1; SMN2RARB | |
| Benzoic Acid SCHEMBL17391496 | 0.92 | TSHR (0.56) | ALDH1A1TP53TSHRSRD5A2RAB9A | |
| Benzoic Acid SCHEMBL2013041 | 0.92 | TSHR (0.56) | ALDH1A1TP53TSHRSRD5A2RAB9A | |
| Aminobenzoic Acid SCHEMBL1257362 | 0.91 | SLC6A3 (0.48) | ALDH1A1TP53TSHRSMN1; SMN2RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163860-A | ESTER INTERCHANGE WITH METHANOL OF BIS-DIOL TEREPHTHALATE INTERMEDIATE | RHONE-POULENC-TEXTILE (FR) | 1979-08-07 | — | — | US | claimed |
| CN-119875088-A | High molecular weight poly (carbonic acid) -terephthalic acid-butanediol ester based on carbon dioxide polycondensation and preparation method thereof | 大连理工大学 | 2025-04-25 | — | — | CN | disclosed |
| US-4163860-A | ESTER INTERCHANGE WITH METHANOL OF BIS-DIOL TEREPHTHALATE INTERMEDIATE | RHONE-POULENC-TEXTILE (FR) | 1979-08-07 | — | — | US | disclosed |