Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 5/20 | 0.48 |
| ▸ | CES1 | P23141 | 5/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL17391496 | 1.00 | TSHR (0.56) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL8439003 | 0.92 | ALDH1A1 (0.54) | TSHRSRD5A2ALDH1A1RAB9ATP53 | |
| Terephthalic Acid SCHEMBL11568016 | 0.92 | ALDH1A1 (0.54) | TSHRSRD5A2ALDH1A1RAB9ATP53 | |
| Terephthalic Acid SCHEMBL2061236 | 0.92 | ALDH1A1 (0.54) | TSHRSRD5A2ALDH1A1RAB9ATP53 | |
| Benzoyl Formic Acid SCHEMBL16114299 | 0.91 | CES2 (0.50) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL29040066 | 0.89 | KMT2A (0.49) | TSHRDAONAPRTALDH1A1TP53 | |
| Isophthalic Acid SCHEMBL6038272 | 0.89 | KMT2A (0.51) | ALDH1A1KMT2A | |
| Benzoic Acid SCHEMBL2463701 | 0.89 | TSHR (0.52) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL29233380 | 0.89 | TSHR (0.52) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL30822815 | 0.88 | TSHR (0.56) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104558284-B | Catalytic component for olefinic polymerization and preparation method thereof and the catalyst for olefinic polymerization and application | 中国石油化工股份有限公司 | 2017-09-29 | — | — | CN | claimed |
| CN-107107564-A | The multilayer intermediate layer of anti-defect formation | 首诺公司 | 2017-08-29 | — | — | CN | claimed |
| CN-104558284-A | Catalyst component used for olefin polymerization and preparation method thereof as well as catalyst used for olefin polymerization and application | CHINA PETROLEUM & CHEMICAL | 2015-04-29 | — | — | CN | claimed |
| WO-2011071674-A1 | ASYMMETRIC CYCLIC DIESTER COMPOUNDS | FERRO CORPORATION (US) | 2011-06-16 | — | — | WO | claimed |
| US-20100113664-A1 | Asymmetric Cyclic Diester Compounds | FERRO CORPORATION (US) | 2010-05-06 | — | — | US | claimed |
| CN-114456289-A | Titanium-containing catalyst, catalyst for olefin polymerization, and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456288-A | Titanium-containing catalyst, catalyst for olefin polymerization reaction, and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-105636779-B | Improved Multilayer panel with reduced edge defect rate | 首诺公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-105682917-B | High fluidity polymer interlayers for laminated glass | 首诺公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-105622794-B | For the catalytic component and catalyst system of olefinic polymerization and its application and olefine polymerizing process | 中国石油化工股份有限公司 | 2018-07-20 | — | — | CN | disclosed |
| CN-105440182-B | Catalyst for polymerization of propylene solid constituent and preparation method thereof and catalyst for polymerization of propylene and its application | 中国石油化工股份有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-107522803-A | Ball type carrier and olefin polymerization catalysis and its preparation method and application and the method for olefinic polymerization | 中国石油化工股份有限公司 | 2017-12-29 | — | — | CN | disclosed |
| CN-105622794-A | Catalyst component and catalyst system for olefin polymerization, application thereof, and olefin polymerization method | CHINA PETROLEUM & CHEM CORP | 2016-06-01 | — | — | CN | disclosed |
| CN-105622793-A | Catalyst component and catalyst system for olefin polymerization, application thereof, and olefin polymerization method | CHINA PETROLEUM & CHEM CORP | 2016-06-01 | — | — | CN | disclosed |
| CN-103087222-A | Olefin polymerization catalyst, process for producing olefin polymer, polypropylene resin composition and article comprising the same | SUMITOMO CHEMICAL CO | 2013-05-08 | — | — | CN | disclosed |
| CN-102137876-A | Catalyst component for olefin polymerization and catalyst comprising the same | CHINA PETROLEUM & CHEMICAL | 2011-07-27 | — | — | CN | disclosed |
| WO-2011071674-A1 | ASYMMETRIC CYCLIC DIESTER COMPOUNDS | FERRO CORPORATION (US) | 2011-06-16 | — | — | WO | disclosed |
| EP-2252656-A1 | BIODEGRADABLE ELASTOMERIC COMPOUND | A.P.I. Applicazioni Plastiche Industriali S.P.A. (IT) | 2010-11-24 | — | — | EP | disclosed |
| US-20100113664-A1 | Asymmetric Cyclic Diester Compounds | FERRO CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| WO-2009112438-A1 | BIODEGRADABLE ELASTOMERIC COMPOUND | A.P.I. APPLICAZIONI PLASTICHE INDUSTRIALI S.P.A. (IT) | 2009-09-17 | — | — | WO | disclosed |