Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 7/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 2/20 | 0.46 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.46 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000447 | 0.89 | CYP11B2 (0.49) | PDK4GRM5GRM1NAMPTKIT | |
| SCHEMBL23210198 | 0.79 | PDK4 (0.63) | PDK4BTKGRM5GRM1NAMPT | |
| SCHEMBL22324934 | 0.78 | GPR119 (0.55) | PDK4GRM5GRM1NAMPTHTR6 | |
| SCHEMBL13077670 | 0.77 | NAMPT (0.44) | NAMPTEEDRBBP4SUZ12EZH2 | |
| SCHEMBL3732875 | 0.76 | CXCR3 (0.48) | NAMPTEEDRBBP4SUZ12EZH2 | |
| SCHEMBL252383 | 0.76 | BTK (0.47) | PDK4BTKGRM5GRM1HTR6 | |
| SCHEMBL23228627 | 0.75 | PDK4 (0.59) | PDK4BTKGRM5GRM1NAMPT | |
| SCHEMBL18129626 | 0.75 | MAP4K1 (0.54) | BTKKIT | |
| SCHEMBL16639119 | 0.75 | PIK3CA (0.54) | BTKPIK3R1PIK3CA | |
| SCHEMBL3436385 | 0.75 | PDK4 (0.69) | PDK4GRM5GRM1NAMPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424840-B1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-08-06 | — | — | EP | disclosed |
| US-8450317-B2 | CXCR3 receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-28 | — | — | US | disclosed |
| US-8450317-B2 | CXCR3 receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-28 | — | — | US | disclosed |
| US-8450317-B2 | CXCR3 receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-28 | — | — | US | disclosed |
| EP-2424840-A1 | CXCR3 RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126811-A1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | WO | disclosed |
| US-20100280028-A1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | US | disclosed |
| US-20100280028-A1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | US | disclosed |
| US-20100280028-A1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280028-A1 | CXCR3 RECEPTOR ANTAGONISTS | CXCR3, CXCR1, CXCR2 | PDK4 1854/4885BTK 695/4885GRM5 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.